This pilot emphasis area within NSF SBIR/STTR programs invests in startups and small businesses developing next-generation scientific instrumentation, novel experimental platforms, and enabling technologies to advance scientific discovery. Funding is available through Phase I, Phase II, Fast-Track, and Supplements, with awards up to $2 million for R&D. The program prioritizes infrastructure for new scientific fields, including AI-driven discoveries, supporting transformative innovations and strengthening the U.S. scientific enterprise.
Eligible applicants are small business concerns with 500 or fewer employees, compliant with SBIR/STTR policies. Phase I requires an invitation after submitting a Project Pitch. Phase II is open only to Phase I awardees. STTR proposals must include a partner research institution.
