This funding opportunity supports investigator-initiated multi-site clinical trials encompassing efficacy, effectiveness, pragmatic, and implementation research. Eligible trials include large, complex, single-site, multi-site, or decentralized designs. Applications must present scientific rationale, operational plans, and comprehensive project coordination including data management and biostatistical support. The award uses a milestone-driven UG3/UH3 mechanism with up to 7 years of funding.
Eligible applicants include state, county, city, and special district governments; educational institutions; tribal governments and organizations; nonprofits; for-profit organizations; small businesses; federal agencies; U.S. territories; faith-based and community organizations; regional and foreign
